Two of the NFL's hottest young quarterbacks will go head to head in maybe the most anticipated cro s-conference matchup of the Week 10 slate on Sunday. Neither the nor the have been considered serious Super Bowl contenders for a while, but both squads are squarely in the mix for a playoff hunt this year, thanks in large part due to the explosive play of their signal-callers -- in Arizona, and in Buffalo.Murray's Cardinals are coming off two straight shootouts, edging the in Week 8 Jim Bunning Jersey before falling to the in Week 9. Allen's Bills, meanwhile, are fresh off two of their own close games, topping the rival in Week 8 and then rolling over the Seahawks a week ago. Which young dual threat will reign supreme this weekend? We'll find out soon enough. In the meantime, here's everything you need to know to prepare yourself for this battle of hopeful contenders:How to watchDate:Sunday, Nov. 15 |Time:4:05 p.m. ETLocation:State Farm Stadium (Glendale, Arizona)TV: CBS|Stream: Follow:PredictionThere are a few intriguing rivalry games on tap for Week 10 (Eagles-Giants, Rams-Seahawks, Bears-Vikings), but it's not a stretch to suggest Bills-Cardinals could be the weekend's most exciting offering. That's also why this one's tough to predict. Both sides have played hard over the last few weeks, with the Cards showcasing their NFL-best offense in consecutive tight games and the Bills stringing together three straight wins after a two-game slide in October. Both have plenty to play for: The Bills are atop the AFC East, but the Dolphins are creeping closer; and the Cardinals are even with the and chasing Seattle in the NFC West.Who's got the edge, then? We tend to agree with the oddsmakers here, who have Arizona as the slight favorite. Not only are the Cards at home for a third straight week, but they have one of the best rushing attacks in the league -- something that should scare Buffalo despite Seattle's weak effort on the ground in Week 9. Josh Allen should make his fair share of plays, but Arizona is also boasting a slightly healthier secondary. They've also allowed fewer points than the Bills this year. Best of all, of course, they've got Kyler Murray running their offensive show. It should be close, and it should be high-scoring, but the safe bet is for Arizona to take one and stay alive in the West.Pick: Cardinals 30, Bills 27Check out CBSSports.comon this game and the rest of Week 10. Tim McCarver Jersey