This essay reviews some of the recent progress in the area of energy conditions and wormholes. Most of the discussion centers on the subject of ``quantum inequality'' restrictions on negative energy. These are bounds on the magnitude and duration of negative energy which put rather severe constraints on its possible macroscopic effects. Such effects might include the construction of wormholes and warp drives for faster-than-light travel, and violations of the second law of thermodynamics. Open problems and future directions are also discussed.